Dense core granule localization

Across TCGA patient cohorts, RNA activity of the Dense core granule localization pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP2, KIF1A, and RNA5SP118, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dense core granule localization activity versus MAP2 in LSCC (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP2 →	+1.787	+0.943	<.001	<.001	3	9
OV	KIF1A →	+1.753	+0.219	<.001	.001	3	8
HNSC	RNA5SP118 →	+1.604	+0.687	<.001	<.001	3	7
LSCC	STARD5 →	-0.422	-0.714	.004	<.001	3	5
OV	NAT8L →	+1.376	+0.351	<.001	<.001	3	5
GBM	ADGRB3 →	+1.035	+0.661	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032253 vs MAP2 — LSCC

Explore this scatter interactively →