Positive regulation of nucleobase-containing compound transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of nucleobase-containing compound transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HMCES, UBXN7, and LSG1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nucleobase-containing compound transport activity versus HMCES in LSCC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HMCES →	+0.371	+0.046	<.001	<.001	3	7
LSCC	UBXN7 →	+0.521	+0.065	<.001	<.001	3	7
LSCC	LSG1 →	+0.466	+0.061	<.001	<.001	3	7
LSCC	ABCF3 →	+0.264	+0.053	<.001	<.001	3	7
HNSC	RFC2 →	+0.468	+0.110	<.001	<.001	3	6
LSCC	SDF2 →	+0.415	+0.051	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032241 vs HMCES — LSCC

Explore this scatter interactively →