Positive regulation of nucleobase-containing compound transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of nucleobase-containing compound transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOR4A, P2RX1, and SATB2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nucleobase-containing compound transport activity versus TOR4A in LSCC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TOR4A →	-0.464	-0.117	.008	.007	3	3
GBM	P2RX1 →	-0.424	-0.166	.001	.001	3	3
COAD	SATB2 →	+0.953	+0.158	.002	.003	3	3
GBM	AVPI1 →	-0.568	-0.212	<.001	.009	3	3
COAD	SATB2-AS1 →	+1.018	+0.154	.001	.003	3	3
LUAD	TP53INP1 →	-0.413	-0.172	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032241 vs TOR4A — LSCC

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