Positive regulation of nucleobase-containing compound transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of nucleobase-containing compound transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED17, FXR2, and MSANTD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED17 grouped by Positive regulation of nucleobase-containing compound transport-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MED17 →	+1.307	+0.150	.004	.006	3	4
OVARY	FXR2 →	+0.561	+0.146	.002	.001	3	4
CNS	MSANTD2 →	+0.631	+0.154	.005	<.001	3	4
BONE	BHLHE40 →	-2.502	-0.229	.006	.003	3	4
BONE	ITPKB →	+1.538	+0.217	.004	.007	3	4
BONE	TEX2 →	-0.686	-0.215	.007	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED17 by Positive regulation of nucleobase-containing compound transport activity — BLOOD_Lymphoma

Explore this box plot interactively →