Positive regulation of nucleobase-containing compound transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of nucleobase-containing compound transport pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PA2G4, HNRNPL, and PCBP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nucleobase-containing compound transport activity versus PA2G4 in SKIN (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PA2G4 →	+0.414	+0.079	.008	.001	3	5
UPPER_AERODIGESTIVE_TRACT	HNRNPL →	+0.812	+0.155	<.001	.001	2	6
UPPER_AERODIGESTIVE_TRACT	PCBP2 →	+1.002	+0.265	.006	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	NUP210 →	+3.108	+0.171	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	EML4 →	+1.060	+0.160	<.001	.001	3	5
BLOOD_Leukemia	HCFC1 →	+0.762	+0.060	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032241 vs PA2G4 — SKIN

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