Regulation of nucleobase-containing compound transport

Across TCGA patient cohorts, RNA activity of the Regulation of nucleobase-containing compound transport pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WRNIP1, SART3, and AKAP8L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nucleobase-containing compound transport activity versus WRNIP1 in HNSC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	WRNIP1 →	+0.288	+0.077	<.001	<.001	3	5
LSCC	SART3 →	+0.236	+0.044	.003	<.001	3	5
LSCC	AKAP8L →	+0.223	+0.038	<.001	<.001	3	5
HNSC	PARP1 →	+0.382	+0.068	<.001	<.001	3	5
BRCA	CLEC3B →	+0.368	+0.024	.004	.004	3	4
OV	CNRIP1 →	+0.630	+0.074	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032239 vs WRNIP1 — HNSC

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