Regulation of nucleobase-containing compound transport

Across TCGA patient cohorts, RNA activity of the Regulation of nucleobase-containing compound transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMELESS, CSE1L, and FEZ1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nucleobase-containing compound transport activity versus TIMELESS in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TIMELESS →	+0.387	+0.430	<.001	<.001	3	5
BRCA	CSE1L →	+0.464	+0.490	<.001	<.001	3	5
BRCA	FEZ1 →	-0.424	-0.387	.002	.006	3	5
BRCA	DACT3 →	-0.681	-0.793	<.001	<.001	3	5
COAD	ABCA8 →	-0.962	-0.842	<.001	<.001	3	5
BRCA	ASF1B →	+0.865	+0.478	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032239 vs TIMELESS — BRCA

Explore this scatter interactively →