Regulation of nucleobase-containing compound transport

Across TCGA cell cohorts, RNA activity of the Regulation of nucleobase-containing compound transport pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPX2, PRRG2, and VIM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPX2 grouped by Regulation of nucleobase-containing compound transport-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GPX2 →	+7.085	+0.253	<.001	<.001	3	5
BLOOD_Leukemia	PRRG2 →	+0.475	+0.246	.002	.004	3	5
URINARY_TRACT	VIM →	-5.997	-0.211	.005	<.001	3	5
LUNG_NSCLC_LUAD	FAAH →	+1.984	+0.219	<.001	<.001	3	4
STOMACH	ANKEF1 →	+1.490	+0.194	.005	.006	2	5
LUNG_NSCLC_LUAD	SYTL2 →	+1.580	+0.137	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPX2 by Regulation of nucleobase-containing compound transport activity — STOMACH

Explore this box plot interactively →