Regulation of nucleobase-containing compound transport

Across TCGA cell cohorts, RNA activity of the Regulation of nucleobase-containing compound transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AURKB, ZBTB10, and PRR3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nucleobase-containing compound transport activity versus AURKB in BLOOD_Leukemia (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AURKB →	+1.019	+0.127	.001	.008	3	8
LIVER	ZBTB10 →	+1.258	+0.227	.003	<.001	3	6
KIDNEY	PRR3 →	+0.826	+0.317	.003	.003	3	6
BONE	MSL2 →	+0.899	+0.366	.002	<.001	3	6
KIDNEY	AARS2 →	+1.000	+0.316	.006	.008	3	5
LUNG_NSCLC_LUAD	RAD1 →	+1.008	+0.121	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032239 vs AURKB — BLOOD_Leukemia

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