Adenosine transport

Across TCGA patient cohorts, RNA activity of the Adenosine transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB3IP, PDZD8, and RRN3P2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenosine transport activity versus RAB3IP in BRCA (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RAB3IP →	-1.615	-0.303	<.001	<.001	3	4
UCEC	PDZD8 →	-1.157	-0.317	.001	.003	3	4
PDAC	RRN3P2 →	+0.401	+0.352	<.001	.001	3	4
PDAC	MTPN →	-0.487	-0.345	.006	.009	3	4
PDAC	PTPRB →	-0.477	-0.287	.002	.001	3	4
PDAC	UACA →	-0.697	-0.356	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032238 vs RAB3IP — BRCA

Explore this scatter interactively →