Adenosine transport

Across TCGA cell cohorts, RNA activity of the Adenosine transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLCG2, MX1, and YBX1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLCG2 grouped by Adenosine transport-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLCG2 →	+1.644	+1.133	<.001	<.001	3	4
PANCREAS	MX1 →	+3.098	+1.388	<.001	.003	3	4
BLOOD_Lymphoma	YBX1 →	-0.619	-1.865	.004	<.001	3	4
CNS	AP1S3 →	-0.780	-0.880	.005	.001	3	3
CNS	NDE1 →	-0.896	-1.287	.001	.001	3	3
STOMACH	ATIC →	-0.798	-1.079	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLCG2 by Adenosine transport activity — LARGE_INTESTINE

Explore this box plot interactively →