Positive regulation of actin filament bundle assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of actin filament bundle assembly pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE1A, MEF2C, and MYL9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of actin filament bundle assembly activity versus PDE1A in CCRCC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PDE1A →	+1.460	+0.623	<.001	<.001	3	6
BRCA	MEF2C →	+0.612	+0.366	<.001	<.001	3	6
BRCA	MYL9 →	+1.097	+0.375	<.001	<.001	3	5
OV	ACTA2 →	+1.793	+0.710	<.001	<.001	3	5
CCRCC	C7 →	+2.640	+0.340	<.001	.007	3	5
BRCA	PLSCR4 →	+0.835	+0.355	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032233 vs PDE1A — CCRCC

Explore this scatter interactively →