Positive regulation of actin filament bundle assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of actin filament bundle assembly pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBA4A, AP1S3, and MAP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TUBA4A grouped by Positive regulation of actin filament bundle assembly-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TUBA4A →	-2.922	-1.078	.001	<.001	3	5
OVARY	AP1S3 →	-0.969	-1.098	.005	.002	3	5
BONE	MAP2 →	+2.498	+1.483	.008	.005	3	4
SOFT_TISSUE	TBC1D13 →	+1.271	+1.438	.003	<.001	3	4
STOMACH	FER →	+1.271	+1.089	.002	.003	3	4
OVARY	EIF4EBP1 →	+1.047	+0.961	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TUBA4A by Positive regulation of actin filament bundle assembly activity — OVARY

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