Positive regulation of actin filament bundle assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of actin filament bundle assembly pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PXDC1, NABP1, and WBP2NL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of actin filament bundle assembly activity versus PXDC1 in BONE (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PXDC1 →	+2.913	+0.234	.001	.008	3	6
BONE	NABP1 →	+1.858	+0.242	.001	.005	3	6
OVARY	WBP2NL →	+0.776	+0.201	<.001	.001	3	6
OVARY	PPP1R13L →	+1.645	+0.280	<.001	<.001	3	6
PANCREAS	TRIM34 →	+1.602	+0.294	.003	.003	3	5
OVARY	TINAGL1 →	+3.460	+0.181	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032233 vs PXDC1 — BONE

Explore this scatter interactively →