Negative regulation of actin filament bundle assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of actin filament bundle assembly pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECH1, EPHB3, and BBS7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ECH1 grouped by Negative regulation of actin filament bundle assembly-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ECH1 →	+0.627	+0.853	.008	.002	3	3
CNS	EPHB3 →	+2.087	+0.809	<.001	.003	3	3
LARGE_INTESTINE	BBS7 →	+0.669	+0.799	.003	.005	3	3
BLOOD_Leukemia	TRAPPC9 →	-1.104	-0.246	.002	<.001	3	3
OVARY	CTXN1 →	-1.184	-0.559	.001	.003	3	3
PANCREAS	TPD52L1 →	+2.080	+0.814	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ECH1 by Negative regulation of actin filament bundle assembly activity — CNS

Explore this box plot interactively →