Regulation of actin filament bundle assembly

Across TCGA patient cohorts, RNA activity of the Regulation of actin filament bundle assembly pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, DCN, and SERBP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of actin filament bundle assembly activity versus RSU1 in COAD (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RSU1 →	+0.403	+0.033	.001	<.001	3	10
CCRCC	DCN →	+1.084	+0.040	<.001	<.001	3	10
OV	SERBP1 →	-0.412	-0.064	<.001	<.001	3	9
COAD	TLN1 →	+0.348	+0.032	<.001	<.001	3	9
CCRCC	TPM1 →	+0.762	+0.043	<.001	<.001	3	9
BRCA	YME1L1 →	-0.282	-0.034	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032231 vs RSU1 — COAD

Explore this scatter interactively →