Regulation of actin filament bundle assembly

Across TCGA patient cohorts, RNA activity of the Regulation of actin filament bundle assembly pathway is significantly associated with the immune infiltration of multiple features, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are GMP, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GMP grouped by Regulation of actin filament bundle assembly-low versus -high activity in BRCA.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GMP →	+0.121	+0.418	.030	.007	1	1

Each partner links to its Q-omics profile. Showing the 1 strongest associations by consensus.

GMP by Regulation of actin filament bundle assembly activity — BRCA

Explore this box plot interactively →