Regulation of actin filament bundle assembly

Across TCGA cell cohorts, RNA activity of the Regulation of actin filament bundle assembly pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF12, TBC1D13, and C1QTNF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLF12 grouped by Regulation of actin filament bundle assembly-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KLF12 →	+1.132	+0.988	.002	<.001	3	4
SOFT_TISSUE	TBC1D13 →	+1.305	+1.262	.001	<.001	3	3
LARGE_INTESTINE	C1QTNF2 →	+0.239	+0.672	.006	.005	3	3
LARGE_INTESTINE	TMEM203 →	+0.358	+0.870	.006	.007	2	4
LIVER	ABTB1 →	+2.151	+0.306	<.001	.002	3	3
LIVER	USP9X →	+0.848	+0.306	.004	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLF12 by Regulation of actin filament bundle assembly activity — SOFT_TISSUE

Explore this box plot interactively →