"Positive regulation of synaptic transmission, GABAergic"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of synaptic transmission, GABAergic" pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THOC2, RNU6-850P, and GCNT2P1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of synaptic transmission, GABAergic" activity versus THOC2 in BRCA (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	THOC2 →	-0.473	-0.801	<.001	<.001	3	3
OV	RNU6-850P →	-0.850	-0.465	.006	<.001	3	3
PDAC	GCNT2P1 →	-0.246	-0.662	.004	<.001	3	3
GBM	RBMS1 →	-0.370	-0.370	.006	.004	3	3
GBM	CCNL1 →	-0.291	-0.459	<.001	.001	3	3
UCEC	TMEM19 →	-0.389	-0.481	.006	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032230 vs THOC2 — BRCA

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