"Regulation of synaptic transmission, GABAergic"

Across TCGA patient cohorts, RNA activity of the "Regulation of synaptic transmission, GABAergic" pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOM1L1, WDFY4, and ACTN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of synaptic transmission, GABAergic" activity versus TOM1L1 in BRCA (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TOM1L1 →	+0.406	+0.034	.002	.001	3	6
LSCC	WDFY4 →	-0.282	-0.037	<.001	<.001	3	6
COAD	ACTN1 →	-0.468	-0.040	<.001	<.001	3	5
CCRCC	AFTPH →	+0.218	+0.033	.002	.004	3	5
BRCA	GLIPR2 →	-0.540	-0.049	<.001	<.001	3	5
UCEC	KCTD12 →	-0.544	-0.049	<.001	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032228 vs TOM1L1 — BRCA

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