"Regulation of synaptic transmission, GABAergic"

Across TCGA cell cohorts, RNA activity of the "Regulation of synaptic transmission, GABAergic" pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VSTM2L, TCTE3, and HACE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VSTM2L grouped by "Regulation of synaptic transmission, GABAergic"-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	VSTM2L →	-1.994	-1.078	<.001	.008	3	4
URINARY_TRACT	TCTE3 →	-1.074	-1.283	.003	.008	3	4
URINARY_TRACT	HACE1 →	-1.133	-1.747	.001	<.001	3	4
LUNG_NSCLC_LUAD	WARS1 →	+0.998	+0.759	.001	.006	2	5
LUNG_NSCLC_LUAD	XPC →	-0.438	-0.621	.001	.004	3	4
BONE	ZMYM1 →	-0.799	-1.542	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VSTM2L by "Regulation of synaptic transmission, GABAergic" activity — SOFT_TISSUE

Explore this box plot interactively →