"Regulation of synaptic transmission, GABAergic"

Across TCGA cell cohorts, RNA activity of the "Regulation of synaptic transmission, GABAergic" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGB2, USP30, and SH3KBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of synaptic transmission, GABAergic" activity versus HMGB2 in LUNG_SCLC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HMGB2 →	+1.125	+0.374	.008	.008	2	5
LUNG_SCLC	USP30 →	+0.675	+0.399	.002	.003	3	4
LUNG_SCLC	SH3KBP1 →	-1.574	-0.338	.006	.001	3	4
URINARY_TRACT	NEDD8 →	+0.746	+1.678	.001	<.001	3	4
URINARY_TRACT	TIMM10 →	+1.201	+1.399	.001	.003	3	4
URINARY_TRACT	NABP2 →	+0.756	+1.732	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032228 vs HMGB2 — LUNG_SCLC

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