"Regulation of synaptic transmission, dopaminergic"

Across TCGA patient cohorts, RNA activity of the "Regulation of synaptic transmission, dopaminergic" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IWS1, ADNP, and RBM12, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of synaptic transmission, dopaminergic" activity versus IWS1 in GBM (Pearson r = -0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IWS1 →	-0.339	-0.098	<.001	<.001	3	7
HNSC	ADNP →	-0.368	-0.119	<.001	<.001	3	7
GBM	RBM12 →	-0.328	-0.097	<.001	<.001	3	7
GBM	FLNA_T2336 →	+0.764	+0.095	<.001	<.001	3	7
GBM	ACIN1 →	-0.296	-0.097	<.001	<.001	3	7
GBM	MFAP1 →	-0.241	-0.066	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032225 vs IWS1 — GBM

Explore this scatter interactively →