"Regulation of synaptic transmission, dopaminergic"

Across TCGA patient cohorts, RNA activity of the "Regulation of synaptic transmission, dopaminergic" pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCL5, FPR2, and N4BP2L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of synaptic transmission, dopaminergic" activity versus CXCL5 in OV (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CXCL5 →	+0.924	+0.198	.005	.001	2	5
LSCC	FPR2 →	+0.780	+0.303	<.001	.001	3	4
LUAD	N4BP2L1 →	-0.335	-0.237	.001	<.001	3	4
LUAD	NLRC3 →	-0.290	-0.175	.004	.002	3	4
PDAC	MS4A4E →	-0.787	-0.218	<.001	<.001	3	4
CCRCC	AQP9 →	+1.091	+0.171	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032225 vs CXCL5 — OV

Explore this scatter interactively →