"Regulation of synaptic transmission, cholinergic"

Across TCGA patient cohorts, RNA activity of the "Regulation of synaptic transmission, cholinergic" pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TMOD1, TPM1, and CSRP1_S192, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of synaptic transmission, cholinergic" activity versus TMOD1 in COAD (Pearson r = -0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TMOD1 →	+0.582	+0.056	<.001	<.001	3	5
COAD	TPM1 →	+0.888	+0.059	<.001	<.001	3	5
PDAC	CSRP1_S192 →	+0.555	+0.056	<.001	.001	3	5
COAD	CACNA2D1 →	+0.593	+0.078	<.001	<.001	3	5
PDAC	LMOD1_S12 →	+0.641	+0.062	<.001	<.001	3	5
UCEC	CD248 →	+0.560	+0.643	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032222 vs TMOD1 — COAD

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