Riboflavin transport

Across TCGA patient cohorts, RNA activity of the Riboflavin transport pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are USP6NL, CTNND1_S269, and DHRS3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Riboflavin transport activity versus USP6NL in OV (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	USP6NL →	+0.526	+0.077	<.001	<.001	3	5
HNSC	CTNND1_S269 →	+0.379	+0.074	.003	.001	3	4
LUAD	DHRS3 →	+0.434	+0.058	.007	.008	3	4
LUAD	KLF5 →	+0.371	+0.075	<.001	.001	3	4
UCEC	TPPP3 →	+1.089	+0.373	<.001	.002	3	4
OV	TUBB6 →	-0.347	-0.054	.006	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032218 vs USP6NL — OV

Explore this scatter interactively →