Riboflavin transport

Across TCGA cell cohorts, RNA activity of the Riboflavin transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STARD10, LPIN1, and RIN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STARD10 grouped by Riboflavin transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	STARD10 →	+1.056	+1.355	<.001	<.001	3	5
SOFT_TISSUE	LPIN1 →	-1.258	-1.234	.004	.001	3	4
BONE	RIN1 →	-3.319	-1.674	.001	<.001	2	5
SOFT_TISSUE	CCDC85B →	-1.953	-1.246	.003	.008	3	4
OESOPHAGUS	WDR90 →	+1.211	+1.601	.002	<.001	3	4
LIVER	ARMC8 →	+0.636	+1.000	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STARD10 by Riboflavin transport activity — CNS

Explore this box plot interactively →