Negative regulation of telomere maintenance via telomerase

Across TCGA patient cohorts, RNA activity of the Negative regulation of telomere maintenance via telomerase pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZC3H18, DCTPP1, and MFSD10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of telomere maintenance via telomerase activity versus ZC3H18 in LSCC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZC3H18 →	+0.187	+0.038	.001	.001	3	5
LSCC	DCTPP1 →	+0.476	+0.039	<.001	<.001	3	5
GBM	MFSD10 →	-0.348	-0.031	<.001	.001	3	5
OV	TUT4_S104 →	+1.943	+0.077	<.001	<.001	3	5
GBM	SIRT1 →	+0.288	+0.033	.002	.004	3	5
COAD	MMAA →	-0.301	-0.024	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032211 vs ZC3H18 — LSCC

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