Negative regulation of telomere maintenance via telomerase

Across TCGA cell cohorts, RNA activity of the Negative regulation of telomere maintenance via telomerase pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FDXR, HEG1, and TRIM16L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FDXR grouped by Negative regulation of telomere maintenance via telomerase-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FDXR →	-1.888	-0.238	.001	<.001	3	5
LUNG_NSCLC_LUAD	HEG1 →	+2.460	+0.186	<.001	<.001	3	4
CNS	TRIM16L →	+1.422	+0.186	<.001	<.001	3	4
BREAST	STARD4 →	+1.243	+0.130	<.001	.001	3	4
PANCREAS	RPH3AL →	-2.059	-0.188	<.001	.003	3	4
KIDNEY	ABL1 →	+1.422	+0.376	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FDXR by Negative regulation of telomere maintenance via telomerase activity — LUNG_SCLC

Explore this box plot interactively →