Negative regulation of telomere maintenance via telomerase

Across TCGA cell cohorts, RNA activity of the Negative regulation of telomere maintenance via telomerase pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOT2, MAGOH, and MRPS22, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of telomere maintenance via telomerase activity versus GOT2 in BLOOD_Lymphoma (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GOT2 →	-0.815	-0.064	.001	.001	3	8
BREAST	MAGOH →	-0.813	-0.117	.001	.004	3	6
STOMACH	MRPS22 →	-0.818	-0.124	.004	.001	3	6
BLOOD_Leukemia	TCF7 →	-3.985	-0.102	.001	.001	3	5
BREAST	PRKAA1 →	-1.046	-0.095	.003	.005	3	5
LUNG_SCLC	NOB1 →	-1.246	-0.147	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032211 vs GOT2 — BLOOD_Lymphoma

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