Positive regulation of telomere maintenance

Across TCGA patient cohorts, RNA activity of the Positive regulation of telomere maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are POGZ, SMC1A, and SMC3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of telomere maintenance activity versus POGZ in HNSC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	POGZ →	+0.227	+0.065	<.001	<.001	3	7
HNSC	SMC1A →	+0.156	+0.060	<.001	.001	3	6
HNSC	SMC3 →	+0.145	+0.064	.003	<.001	3	6
LSCC	ADNP →	+0.302	+0.035	.008	.005	3	6
LSCC	GATAD2B →	+0.307	+0.046	.001	<.001	3	6
LUAD	MSH6 →	+0.470	+0.038	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032206 vs POGZ — HNSC

Explore this scatter interactively →