Positive regulation of telomere maintenance

Across TCGA patient cohorts, RNA activity of the Positive regulation of telomere maintenance pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S1PR1, C11orf96, and AKR1C3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of telomere maintenance activity versus S1PR1 in GBM (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	S1PR1 →	-0.570	-0.163	.001	<.001	3	5
LUAD	C11orf96 →	-0.815	-0.157	.002	.001	3	5
LUAD	AKR1C3 →	-1.673	-0.172	.001	<.001	3	5
BRCA	RTN4 →	-0.393	-0.181	<.001	<.001	3	5
BRCA	PLPP3 →	-0.601	-0.160	.002	.003	3	5
GBM	BCAS1 →	-1.455	-0.154	.005	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032206 vs S1PR1 — GBM

Explore this scatter interactively →