Positive regulation of telomere maintenance

Across TCGA cell cohorts, RNA activity of the Positive regulation of telomere maintenance pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CGN, ZNF552, and SACS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of telomere maintenance activity versus CGN in OVARY (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CGN →	-3.157	-0.359	.006	.001	3	5
OVARY	ZNF552 →	-1.206	-0.293	<.001	.001	3	5
BLOOD_Myeloma	SACS →	+1.246	+0.216	.003	<.001	3	5
BREAST	USP45 →	+0.411	+0.142	.008	.007	3	4
OVARY	TKT →	+1.170	+0.309	.007	.002	3	4
BLOOD_Myeloma	PITPNM2 →	+1.364	+0.198	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032206 vs CGN — OVARY

Explore this scatter interactively →