Negative regulation of telomere maintenance

Across TCGA patient cohorts, RNA activity of the Negative regulation of telomere maintenance pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HELLS, FOXM1, and CHAF1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of telomere maintenance activity versus HELLS in LSCC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HELLS →	+0.787	+0.193	.002	<.001	3	6
BRCA	FOXM1 →	+0.973	+0.261	.001	<.001	3	5
GBM	CHAF1B →	+0.617	+0.338	.001	.003	3	5
LSCC	MYB →	+1.442	+0.142	<.001	<.001	3	5
HNSC	SGO1 →	+0.404	+0.143	.004	.001	3	5
HNSC	ZDHHC23 →	+0.601	+0.190	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032205 vs HELLS — LSCC

Explore this scatter interactively →