Negative regulation of telomere maintenance

Across TCGA cell cohorts, RNA activity of the Negative regulation of telomere maintenance pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNH, MRPL2, and UBE2J1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of telomere maintenance activity versus CCNH in STOMACH (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CCNH →	-1.038	-0.173	.005	<.001	3	7
SOFT_TISSUE	MRPL2 →	-0.392	-0.130	.001	.004	3	5
LUNG_NSCLC_LUSC	UBE2J1 →	-0.950	-0.127	.003	<.001	3	5
OESOPHAGUS	DPM1 →	-0.999	-0.161	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	AASDHPPT →	-0.859	-0.207	.003	.002	3	5
KIDNEY	HARS1 →	-0.544	-0.113	.003	.006	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032205 vs CCNH — STOMACH

Explore this scatter interactively →