Regulation of telomere maintenance

Across TCGA patient cohorts, RNA activity of the Regulation of telomere maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GATAD2B, PSIP1, and STIM1_S257, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of telomere maintenance activity versus GATAD2B in LSCC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GATAD2B →	+0.327	+0.045	.002	.001	3	7
GBM	PSIP1 →	+0.602	+0.038	<.001	.001	3	7
CCRCC	STIM1_S257 →	-0.599	-0.016	.001	.009	3	6
CCRCC	SLC16A3_S436 →	-0.950	-0.020	<.001	.003	3	6
LSCC	SMARCC2 →	+0.266	+0.044	<.001	<.001	3	5
HNSC	SMC1A →	+0.261	+0.073	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032204 vs GATAD2B — LSCC

Explore this scatter interactively →