Regulation of telomere maintenance

Across TCGA patient cohorts, RNA activity of the Regulation of telomere maintenance pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1QTNF7, TGIF1, and ZNF25, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of telomere maintenance activity versus C1QTNF7 in BRCA (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C1QTNF7 →	-0.815	-0.242	<.001	<.001	3	4
CCRCC	TGIF1 →	-0.491	-0.172	<.001	.007	3	4
BRCA	ZNF25 →	-0.626	-0.254	<.001	<.001	3	4
COAD	STAM2 →	-0.263	-0.135	.007	<.001	3	3
BRCA	NFE2L2 →	-0.515	-0.235	<.001	<.001	3	3
COAD	NEK1 →	-0.295	-0.094	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032204 vs C1QTNF7 — BRCA

Explore this scatter interactively →