Regulation of telomere maintenance

Across TCGA cell cohorts, RNA activity of the Regulation of telomere maintenance pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A1, SLC23A2, and H2AC14, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A1 grouped by Regulation of telomere maintenance-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SLC25A1 →	+0.318	+0.123	.001	.003	3	7
OVARY	SLC23A2 →	+0.286	+0.177	<.001	.002	2	8
CNS	H2AC14 →	-0.207	-0.114	<.001	.006	3	6
LUNG_NSCLC_LUAD	TCF3 →	+0.234	+0.135	.001	<.001	3	5
BLOOD_Leukemia	RAB21 →	+0.183	+0.148	.004	.005	2	6
OESOPHAGUS	TTC32 →	+0.294	+0.104	.003	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A1 by Regulation of telomere maintenance activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →