Telomere maintenance via semi-conservative replication

Across TCGA cell cohorts, RNA activity of the Telomere maintenance via semi-conservative replication pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf43, RSRC1, and FAM174C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C1orf43 grouped by Telomere maintenance via semi-conservative replication-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	C1orf43 →	+0.916	+0.356	.004	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	RSRC1 →	+0.637	+0.258	.002	.001	3	3
UPPER_AERODIGESTIVE_TRACT	FAM174C →	+0.768	+0.232	.003	.005	3	3
SOFT_TISSUE	EFHC1 →	-0.947	-0.272	.003	.001	3	3
BLOOD_Myeloma	ZMYM6 →	+0.714	+0.502	.007	.001	3	3
LARGE_INTESTINE	ISCU →	+0.644	+0.243	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C1orf43 by Telomere maintenance via semi-conservative replication activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →