Telomere maintenance via semi-conservative replication

Across TCGA cell cohorts, RNA activity of the Telomere maintenance via semi-conservative replication pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF639, ACTL6A, and CDC6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere maintenance via semi-conservative replication activity versus ZNF639 in BLOOD_Lymphoma (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZNF639 →	+0.955	+0.187	<.001	<.001	3	6
LIVER	ACTL6A →	+0.776	+0.291	.008	.001	3	6
PANCREAS	CDC6 →	+1.435	+0.307	<.001	<.001	3	6
BLOOD_Leukemia	RAE1 →	+0.424	+0.135	.002	<.001	3	6
OVARY	GINS3 →	+1.139	+0.234	<.001	.001	3	6
OESOPHAGUS	HAUS8 →	+0.732	+0.188	.001	.003	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032201 vs ZNF639 — BLOOD_Lymphoma

Explore this scatter interactively →