Telomere organization

Across TCGA cell cohorts, RNA activity of the Telomere organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC150, ESPL1, and PIF1, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere organization activity versus CCDC150 in BLOOD_Myeloma (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CCDC150 →	+1.452	+0.070	<.001	<.001	3	20
BLOOD_Myeloma	ESPL1 →	+1.360	+0.045	.001	.007	3	19
BONE	PIF1 →	+1.541	+0.071	<.001	<.001	3	19
BONE	ZGRF1 →	+1.359	+0.090	.001	.001	3	19
UPPER_AERODIGESTIVE_TRACT	CAD →	+1.358	+0.103	<.001	<.001	3	18
SOFT_TISSUE	DNA2 →	+1.251	+0.074	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032200 vs CCDC150 — BLOOD_Myeloma

Explore this scatter interactively →