Telomere organization

Across TCGA cell cohorts, RNA activity of the Telomere organization pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL49, RBM38, and SF3B2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere organization activity versus MRPL49 in LARGE_INTESTINE (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MRPL49 →	+0.590	+0.158	<.001	<.001	3	6
BLOOD_Lymphoma	RBM38 →	+1.068	+0.081	.005	.003	3	6
LARGE_INTESTINE	SF3B2 →	+0.495	+0.119	.007	.007	3	5
LIVER	SART1 →	+0.510	+0.119	.007	.009	3	5
SKIN	TIMM10 →	+0.501	+0.131	.002	<.001	3	5
SKIN	ZNRD2 →	+0.651	+0.145	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032200 vs MRPL49 — LARGE_INTESTINE

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