Activation of protein kinase activity

Across TCGA patient cohorts, RNA activity of the Activation of protein kinase activity pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CARD16, ICAM1, and ARHGAP45, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation of protein kinase activity activity versus CARD16 in UCEC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CARD16 →	+0.595	+0.039	<.001	.004	3	7
LSCC	ICAM1 →	+0.777	+0.032	<.001	<.001	3	7
GBM	ARHGAP45 →	+0.647	+0.060	<.001	<.001	3	7
GBM	APOBR →	+0.512	+0.053	<.001	<.001	3	7
GBM	RIPK3 →	+0.500	+0.047	<.001	<.001	3	6
LSCC	TRIM21 →	+0.452	+0.035	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032147 vs CARD16 — UCEC

Explore this scatter interactively →