Activation of protein kinase activity

Across TCGA cell cohorts, RNA activity of the Activation of protein kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTMR14, PHF13, and SLC35A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation of protein kinase activity activity versus MTMR14 in SOFT_TISSUE (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MTMR14 →	+0.653	+0.214	<.001	.002	3	5
OESOPHAGUS	PHF13 →	+0.742	+0.236	.007	.005	3	5
SOFT_TISSUE	SLC35A2 →	-0.728	-0.315	.007	.003	3	5
LIVER	VHL →	+1.467	+0.189	<.001	.008	2	5
OESOPHAGUS	TTC33 →	+1.290	+0.322	.008	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	RAB6B →	+0.874	+0.581	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032147 vs MTMR14 — SOFT_TISSUE

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