Regulation of appetite

Across TCGA patient cohorts, RNA activity of the Regulation of appetite pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RUFY1, KIFC1, and ACTR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of appetite activity versus RUFY1 in LSCC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RUFY1 →	+0.232	+0.063	.002	<.001	3	5
LSCC	KIFC1 →	-0.643	-0.074	<.001	<.001	3	5
PDAC	ACTR2 →	+0.183	+0.049	.001	.006	3	4
HNSC	ADNP_S608 →	-0.463	-0.073	.001	.001	3	4
PDAC	DENND2B_S357 →	+0.625	+0.050	.003	.005	3	4
PDAC	KRT6A →	+1.290	+0.052	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032098 vs RUFY1 — LSCC

Explore this scatter interactively →