Regulation of appetite

Across TCGA patient cohorts, RNA activity of the Regulation of appetite pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC6, FAM229B, and KIF6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of appetite activity versus DNAJC6 in GBM (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DNAJC6 →	+0.950	+0.204	<.001	<.001	3	5
GBM	FAM229B →	+0.467	+0.181	.002	.001	3	5
GBM	KIF6 →	+0.701	+0.195	<.001	.001	3	4
GBM	CES4A →	+0.899	+0.212	<.001	<.001	3	4
GBM	ARFGEF3 →	+0.600	+0.162	.006	.004	3	4
BRCA	KIF12 →	+1.209	+0.097	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032098 vs DNAJC6 — GBM

Explore this scatter interactively →