Regulation of appetite

Across TCGA cell cohorts, RNA activity of the Regulation of appetite pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF4G2, RIC8A, and SLC25A30, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF4G2 grouped by Regulation of appetite-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	EIF4G2 →	+0.777	+1.590	<.001	.004	2	5
BONE	RIC8A →	+0.868	+1.228	.001	.003	3	4
OVARY	SLC25A30 →	-0.990	-0.979	.003	.006	3	4
OVARY	FGFR1 →	-2.755	-1.178	.002	.003	3	4
UPPER_AERODIGESTIVE_TRACT	B4GALT2 →	-0.796	-1.643	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	PDIA5 →	-0.904	-1.285	.004	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF4G2 by Regulation of appetite activity — BLOOD_Myeloma

Explore this box plot interactively →