Negative regulation of response to food

Across TCGA patient cohorts, RNA activity of the Negative regulation of response to food pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXL5, TMCO1, and TMEM167B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to food activity versus FBXL5 in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FBXL5 →	+0.582	+0.156	.001	<.001	3	4
LUAD	TMCO1 →	+0.349	+0.189	.009	.001	3	4
BRCA	TMEM167B →	+0.473	+0.135	<.001	.004	3	4
BRCA	ELMOD2 →	+0.529	+0.138	<.001	.001	3	4
GBM	SEPTIN4 →	+1.023	+0.194	<.001	<.001	3	4
GBM	ST3GAL4 →	+0.327	+0.136	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032096 vs FBXL5 — BRCA

Explore this scatter interactively →