Negative regulation of response to food

Across TCGA patient cohorts, RNA activity of the Negative regulation of response to food pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BBS4, BBS1, and C6orf132_T297, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to food activity versus BBS4 in BRCA (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BBS4 →	+0.385	+0.142	<.001	<.001	3	4
BRCA	BBS1 →	+0.733	+0.157	<.001	<.001	3	4
CCRCC	C6orf132_T297 →	+1.016	+0.283	<.001	.001	3	3
PDAC	AEBP2_T242 →	-0.790	-0.413	.004	.003	3	3
UCEC	APC_S2512 →	+0.554	+0.155	<.001	<.001	3	3
GBM	PACSIN1 →	+0.769	+0.196	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032096 vs BBS4 — BRCA

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