Negative regulation of response to food

Across TCGA cell cohorts, RNA activity of the Negative regulation of response to food pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEX3, CST3, and MITF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PEX3 grouped by Negative regulation of response to food-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PEX3 →	+0.591	+1.152	.002	<.001	3	4
OVARY	CST3 →	-1.135	-1.256	<.001	<.001	3	4
OVARY	MITF →	-1.564	-1.063	.004	.004	3	4
OVARY	SLC22A5 →	-1.272	-1.510	.005	<.001	3	4
OVARY	PDIA5 →	-0.821	-1.189	.003	<.001	3	4
BLOOD_Myeloma	TMEM41B →	+1.058	+1.886	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PEX3 by Negative regulation of response to food activity — PANCREAS

Explore this box plot interactively →